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PFAS — Per- and Polyfluoroalkyl Substances

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PFAS Home Page
About ITRC
Navigating This Website
PFAS Fact Sheets
1 Introduction
2 Naming Conventions and Use
2 PFAS Chemistry and Naming Conventions, History and Use of PFAS, and Sources of PFAS Releases to the Environment overview
2.1 Environmental Significance
2.2 Chemistry, Terminology, and Acronyms
2.3 Emerging Health and Environmental Concerns
2.4 PFAS Reductions and Alternative PFAS Formulations
2.5 PFAS Uses and Products
2.6 PFAS Releases to the Environment
3 Firefighting Foams
3 Firefighting Foams Overview
3.1 Foam Formulations
3.2 AFFF Characteristics
3.3 Mechanisms for Release to the Environment
3.4 AFFF Fate and Transport
3.5 Forensic Analysis of AFFF
3.6 AFFF Procurement and Inventory
3.7 Foam Systems and Operations
3.8 Emergency Firefighting Operations
3.9 Immediate Investigative and Cleanup Actions
3.10 AFFF Disposal
3.11 Firefighting Foam System Replacement
3.12 Federal, State and International Regulations and Guidance
3.13 Foam Research and Development
4 Physical and Chemical Properties
4 Physical and Chemical Properties Overview
4.1 Challenges and Limitations Related to PFAS Physical and Chemical Properties
4.2 Physical Properties
4.3 Chemical Properties
5 Fate and Transport
5 Environmental Fate and Transport Processes Overview
5.1 Fate and Transport Introduction
5.2 Phase Partitioning
5.3 Media-Specific Migration Processes
5.4 Transformations
5.5 PFAS Uptake into Aquatic Organisms
5.6 PFAS Uptake into Plants
6 Occurrence
6 Media-Specific Occurrence Overview
6.1 Air
6.2 Soil, Sediment, and Biosolids
6.3 Groundwater
6.4 Surface Water
6.5 Biota
7 Health Effects
7 Human and Ecological Health Effects of select PFAS Overview
7.1 Human Health Effects
7.2 Ecological Toxicology
8 Basis of Regulations
8 Basis of Regulations Overview
8.1 Introduction
8.2 Regulatory Programs
8.3 Differences in the Available Regulations, Advisories, and Guidance Regulatory
9 Site Risk Assessment
9 Site Risk Assessment Overview
9.1 Human Health Risk Assessment
9.2 Ecological Risk Assessment
9.3 Uncertainty
10 Site Characterization
10 Site Characterization Overview
10.1 Site Characterization Issues Relevant to PFAS
10.2 Initial Steps
10.3 Site Investigation
10.4 Data Analysis and Interpretation
10.5 Forensics and Source Identification
11 Sampling and Analysis
11 Sampling and Analysis Overview
11.1 Sampling
11.2 Analytical Methods/Techniques
11.3 Data Evaluation
11.4 Source Identification
12 Treatment Technologies
12 Treatment Technologies Overview
12.1 Overview
12.2 Field-Implemented Liquids Treatment Technologies
12.3 Field-Implemented Solids Treatment Technologies
12.4 Incineration
12.5 Air Treatment Technologies
12.6 Limited Application and Developing Liquids Treatment Technologies
12.7 Limited Application and Developing Solids Treatment Technologies
12.8 Integrated Water Treatment Solutions
12.9 Sustainability of PFAS Treatment
12.10 Improving Evaluation of PFAS Treatment Technologies
13 Stakeholder Perspectives
13 Stakeholder Perspectives Overview
13.1 Stakeholder Concerns
13.2 Specific Tribal Stakeholder Concerns
13.3 Stakeholder Resources
14 Risk Communication
14 Risk Communication Overview
14.1 Role of Risk Perception: Public Stakeholders and Decision Makers
14.2 Risk Communication Challenges
14.3 Risk Communication Planning and Engagement Tools
15 Case Studies
15 Case Studies Overview
15.1 Site Characterization Case Studies
15.2 Treatment Case Studies
15.3 Risk Assessment Case Study
15.4 Risk Communication Case Studies
15.5 Surface Water Quality Case Studies
16 Surface Water Quality
16 Surface Water Quality
16.1    Introduction
16.2 Protection of Human Health
16.3 Protection of Biota
16.4 Sampling and Analysis
16.5 Surface Water Foam
16.6 Effluent Limits for PFAS
16.7 Surface Water/Groundwater Interaction
17 Additional Information
17 Additional Information Overview
17.1 Additional Information for Media-Specific Occurrence
17.2 Additional Information for Human Health Effects
17.3 Additional Information for Risk Assessment
References
Acronyms
Glossary
Acknowledgments
Team Contacts
Document Feedback

 

PFAS — Per- and Polyfluoroalkyl Substances
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PFAS Home Page

PFAS

PFAS Technical and Regulatory Guidance Document

The last full update of this document was September 2023.

⇐ ONLINE DOCUMENT: On this web page, use the Table of Contents shown in the left-hand navigation column to select a specific section of interest. The last full update of this document was September 2023. Some references were added and updated in May 2024, November 2024, and April 2025. For example, USEPA Method 1633 is now Revision A, and referenced as Method 1633A; the USEPA MCLs were finalized; the USEPA PFAS Destruction and Disposal Guidance Version 2 was published; and several USEPA toxicity assessments were finalized.

2024-25: The PFAS Team is working on additional content for PFAS that will be linked to the existing material when published.

Additional resources developed by ITRC are linked below:

PFAS Fact Sheets

Links for the various ITRC PFAS fact sheets as PDF files. 

Data Tables

Tables developed to provide additional data and information to support various PFAS topics.

Training Resources

Various webinars and videos archived for on demand viewing. 

 

Full Guidance Document (PDF)

 

Published by the Interstate Technology & Regulatory Council, September 2023

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